Niakan, Mahsa; Masteri-Farahani, Majid; Karimi, Sabah; Shekaari, Hemayat published an article in 2021. The article was titled 《Hydrophilic role of deep eutectic solvents for clean synthesis of biphenyls over a magnetically separable Pd-catalyzed Suzuki-Miyaura coupling reaction》, and you may find the article in Journal of Molecular Liquids.Electric Literature of C7H4BrN The information in the text is summarized as follows:
In the present work, a heterogeneous Pd catalyst was synthesized through a green method and deep eutectic solvents (DESs) as green reaction media were used. In order to prepare the catalyst, magnetite-graphene oxide nanocomposite was modified with cellulose via the click reaction and applied as support for Pd nanoparticles. Cellulose acted as both reducing and stabilizing agent for Pd nanoparticles and eliminated the requirement of a reducing agent. The prepared catalyst was characterized by different methods such as FT-IR, EDX, EDX-mapping, XPS, SEM, TEM, XRD, VSM and ICP-OES analyses. Catalytic properties of the obtained catalyst was explored in the Suzuki-Miyaura coupling reaction of aryl halides with aryl boronic acids to afford biphenyls R-R1 [R = Ph, 2-MeC6H4, 4-HOC6H4, etc.; R1 = Ph, 2-thienyl, 4-MeC6H4, 4-O2NC6H4] in different hydrophilic and hydrophobic DESs. The presence of cellulose with hydrophilic character on the structure of catalyst offered well dispersion of the catalyst in hydrophilic DESs, which led to enhancement of its catalytic activity. This simple and new separation strategy provided a clean and highly efficient synthetic methodol. for the synthesis of various biphenyls. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzonitrile(cas: 623-00-7Electric Literature of C7H4BrN)
4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Electric Literature of C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts