Luo, Min; Groaz, Elisabetta; De Jonghe, Steven; Schols, Dominique; Herdewijn, Piet published the artcile< Synthesis and anti-HIV activity of guanine modified fluorinated acyclic nucleoside phosphonate derivatives>, SDS of cas: 69205-79-4, the main research area is acyclic nucleoside phosphonate preparation anti HIV activity evaluation; HIV; Mitsunobu reaction, prodrugs; acyclic nucleoside phosphonates; antiviral activity; cytotoxicity.
The preparation of an unprecedented series of nucleobase-modified 3-fluoro-2-(phosphonomethoxy)propyl (FPMP) acyclic nucleosides in both their (R) and (S) enantiomerically pure forms is described. The synthesis focused on a Mitsunobu alkylation reaction to construct the C-N(9) bond between a chiral fluorinated side-chain residue and 6- or 7-modified guanine analogs. Prodrugs of FPMP-7-deazaguanine were also synthesized by derivatization of the corresponding phosphonic acid functionality with (bis)diamyl aspartate amidate groups, leading to moderate activity against human immunodeficiency virus type 1 (HIV-1).
Chemistry & Biodiversity published new progress about Anti-HIV agents. 69205-79-4 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H5N5O, SDS of cas: 69205-79-4.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts