Liu, Quan; Lu, Zhongxiang; Ren, Wenfei; Shen, Kaibo; Wang, Yu; Xu, Qing published an article in Chinese Journal of Chemistry. The title of the article was 《Efficient synthesis of unsymmetrical heteroaryl ethers by a transition metal-free C-O cross-coupling reaction of activated and unactivated heteroaryl chlorides with alcohols and phenols》.Application In Synthesis of 6-Phenoxynicotinonitrile The author mentioned the following in the article:
By optimizing the reaction conditions via a careful screening of the bases and solvents, an efficient transition metal-free method for C-O cross-coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcs. and phenols was developed, providing a simple, efficient, and practical method for the synthesis of the useful unsym. heteroaryl alkyl and heteroaryl aryl ethers. The experimental part of the paper was very detailed, including the reaction process of 6-Phenoxynicotinonitrile(cas: 99902-72-4Application In Synthesis of 6-Phenoxynicotinonitrile)
6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 6-Phenoxynicotinonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts