In 2019,Advanced Synthesis & Catalysis included an article by Li, Qianqian; He, Xinwei; Tao, Jiajia; Xie, Mengqing; Wang, Hui; Li, Ruxue; Shang, Yongjia. Safety of 3-Oxo-3-phenylpropanenitrile. The article was titled 《Base-mediated 1,4-Conjugate Addition/Intramolecular 5-exo-dig Annulation of Propargylamines with Benzoylacetonitriles and β-Keto Esters for Polysubstituted Furans and Furo[3,4-c]coumarins Formation》. The information in the text is summarized as follows:
A novel and one-pot domino reaction of propargylamines with benzoylacetonitriles and β-keto esters for the regiospecific synthesis of polysubstituted furans I [R1 = H, Me, Br, etc.; R2 = H, tBu; Ar1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; Ar2 = Ph, 4-MeOC6H4, 4-F3CC6H4, etc.] and furo[3,4-c]coumarins II [R3 = H, OMe, Br, etc; R4 = H, tBu; R5 = Me, 2-furyl, Ph, etc.; Ar3 = Ph, 4-FC6H4, 4-EtC6H4, etc.] were developed in moderate to good yields. The reaction was proceed by sequential 1,4-conjugate addition of benzoylacetonitriles/β-keto esters to propargylamines, 5-exo-dig annulation/isomerization to form compounds I and intramol. transesterification to compounds II. The features of this method included use of inexpensive and environmentally friendly carbonates as the base, readily available substrates, high regioselectivity and convenient operation. In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Safety of 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts