Kozlov, Maxim V.; Kleymenova, Alla A.; Romanova, Lyudmila I.; Konduktorov, Konstantin A.; Smirnova, Olga A.; Prasolov, Vladimir S.; Kochetkov, Sergey N. published the artcile< Benzohydroxamic acids as potent and selective anti-HCV agents>, SDS of cas: 21423-84-7, the main research area is benzohydroxamic Hepatitis C Poliomyelitis structure activity preparation; Benzohydroxamic acids; Hepatitis C virus; Metal-depending enzymes; Poliomyelitis virus.
A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, SDS of cas: 21423-84-7.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts