Reference of 4-Cyano-3-fluorophenyl 4-butylbenzoateOn September 26, 1984 ,《The synthesis and transition temperatures of benzoate ester derivatives of 2-fluoro-4-hydroxy- and 3-fluoro-4-hydroxybenzonitriles》 was published in Helvetica Chimica Acta. The article was written by Kelly, Stephen M.. The article contains the following contents:
2-FC6H4OMe was brominated in CHCl3 to 92% 2,4-FBrC6H3OMe which was cyanated to 58% 3,4-F(MeO)C6H3CN. This was demethylated with AlCl3-NaCl to 66% 3,4-F(HO)C6H3CN which was esterified with 4-Me(CH2)4C6H4COCl in PhMe to 62% I [R = Me(CH2)4]. Prepared by the same procedure were 59 other ethers I-IV (R = alkyl, alkoxy). The nematic-isotropic liquid transition temperatures of most of these model esters are only slightly lower than those of the corresponding esters having a H atom in place of F. In several cases, the clearing points of the fluorophenyl esters are higher than those of the unsubstituted Ph esters. The nematic ranges of several of the new esters are markedly broader than those of the analogous non-F substituted Ph esters. In the experiment, the researchers used many compounds, for example, 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Reference of 4-Cyano-3-fluorophenyl 4-butylbenzoate)
4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Reference of 4-Cyano-3-fluorophenyl 4-butylbenzoate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts