Guo, Wei; Cai, Liuhuan; Xie, Zhen; Mei, Weijie; Liu, Gongping; Deng, Ling; Zhuo, Xiaoya; Zhong, Yumei; Zou, Xiaoying; Zheng, Lvyin; Fan, Xiaolin published the artcile< Photocatalyzed intermolecular amination for the synthesis of hydrazonamides>, Category: nitriles-buliding-blocks, the main research area is hydrazonamide preparation diastereoselective; ketonitrile disubstituted hydrazine amination photocatalyst.
A sequential multi-component reaction of β-ketonitriles with N,N-disubstituted hydrazines is designed and developed through a photocatalyzed intermol. amination process to afford hydrazonamides I [R = Et, Ph, 2-furyl, etc.; R1 = Me, Et, n-Pr, etc.; R2 = Ph, 3-MeC6H4, 4-ClC6H4, etc.]. This work reported the first example of the use of N,N-disubstituted hydrazines as two different “”amine”” sources, characterized by isotope labeling experiments The C-CN/N-N bonds were cleaved and new C-N/C=N bonds were constructed in a one-pot reaction. This protocol could be carried out without the addition of any external metals, ligands, bases, oxidants and reductants, and possessed the advantages of operational simplicity, mild reaction conditions, and good functional group tolerance. Furthermore, this approach enabled late-stage modifications of structurally complex bioactive mols., natural products and drugs, thus showing potential applications in the field of organo-pharmaceutical chem.
Organic Chemistry Frontiers published new progress about Amination. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts