Gharui, Chandan; Parida, Chandrakanta; Pan, Subhas Chandra published the artcile< Organocatalytic Asymmetric Addition of Aromatic α-Cyanoketones to o-Quinone Methides: Synthesis of 3,4-Dihydrocoumarins and Tetra-Substituted Chromans>, HPLC of Formula: 21667-62-9, the main research area is acetylnitrile phenylsulfonylmethyl phenol organocatalyst enantioselective cycloaddition reaction; phenyldihydrocoumarin phenyl cyanochroman preparation.
The first organocatalytic asym. addition of aromatic α-cyanoketones to in situ- generated o-quinone methides was developed. The products 3,4-dihydrocoumarin and tetra-substituted chroman were obtained via bifunctional squaramide catalyzed conjugate addition reaction to in situ- generated o-quinone methides followed by treatment with 0.7 N HCl. With 10 mol % of the catalyst, the desired products were obtained in high enantio- and diastereoselectivities.
Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (stereoselective). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, HPLC of Formula: 21667-62-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts