In 2022,Gao, Hongjie; Chen, Jia-Yi; Peng, Zhiqiang; Feng, Lei; Tung, Chen-Ho; Wang, Wenguang published an article in Journal of Organic Chemistry. The title of the article was 《Bioinspired Iron-Catalyzed Dehydration of Aldoximes to Nitriles: A General N-O Redox-Cleavage Method》.Recommanded Product: 2-Bromobenzonitrile The author mentioned the following in the article:
An efficient iron catalyst, Cp*Fe(1,2-Cy2PC6H4O), which rapidly converts various aliphatic and aromatic aldoximes RCH=NOH [R = Pr, Ph, 2H-1,3-benzodioxol-5-yl, etc.] to nitriles RCN with release of H2O at room temp was reported. The catalysis involves redox activation of the N-O bond by a 1e- transfer from the iron catalyst to the oxime. Such redox-mediated N-O cleavage was demonstrated by the isolation of a ferrous iminato intermediate from the reaction of the ketoxime substrate. This iron-catalyzed acceptorless dehydration approach represents a general method for the preparation of nitriles, and it also delivers salicylonitriles R1CN(2-OH) [R1 = Ph, 3-methoxyphenyl, naphthalen-1-yl, etc.] catalyzing the Kemp elimination reaction. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts