Ding, Wei-Yi; Ai, Jun; Wang, Xin-Long; Qiu, Fayang G.; Lv, Qing; Fang, Ping; Hou, Fan-Fan; Yan, Yong-Ming; Cheng, Yong-Xian published the artcile< Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran A>, Category: nitriles-buliding-blocks, the main research area is lingzhifuran A isolation Ganoderma lucidum preparation; lingzhilactone D E F isolation Ganoderma lucidum; phosphorylation inhibitor lingzhifuran A lingzhilactone D; renal fibrosis inhibitor lingzhifuran A lingzhilactone D.
Lingzhifuran A (I) and lingzhilactones D, E, and F, II, III, and IV, four new phenolic meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were identified by spectroscopic data. Chiral HPLC anal. indicates the racemic nature of II-IV. Chiral separation followed by X-ray diffraction anal. discloses the absolute configuration of (-)-II. Compounds I and II could selectively inhibit TGF-β1-induced Smad3 phosphorylation in rat renal tubular epithelial cells, representing novel scaffolds of selective Smad3 activation inhibitors. Total synthesis accompanied by in vivo rodent experiments reveals antifibrotic activities of I against kidney fibrosis. Finally, a plausible biosynthetic pathway for I was proposed.
RSC Advances published new progress about Antifibrotic agents. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts