Carny, Tomas; Rocaboy, Ronan; Clemenceau, Antonin; Baudoin, Olivier published the artcile< Synthesis of Amides and Esters by Palladium(0)-Catalyzed Carbonylative C(sp3)-H Activation>, Reference of 886761-96-2, the main research area is amide ester preparation palladium catalyst carbonylative activation alkoxycarbonylation aminocarbonylation; C−H activation; amides; carbonylation; domino reactions; palladium.
The 1,4-palladium shift strategy allows the functionalization of remote C-H bonds that are difficult to reach directly. Reported here is a domino reaction proceeding by C(sp3)-H activation, 1,4-palladium shift, and amino- or alkoxycarbonylation, which generates a variety of amides and esters bearing a quaternary β-carbon atom. Mechanistic studies showed that the aminocarbonylation of the σ-alkylpalladium intermediate arising from the palladium shift is fast using PPh3 as the ligand, and leads to the amide rather than the previously reported indanone product.
Angewandte Chemie, International Edition published new progress about Alkoxycarbonylation. 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Reference of 886761-96-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts