Cao, Guang-Mei; Hu, Xin-Long; Liao, Li-Li; Yan, Si-Shun; Song, Lei; Chruma, Jason J.; Gong, Li; Yu, Da-Gang published their research in Nature Communications on December 31 ,2021. The article was titled 《Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2》.Application In Synthesis of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile The article contains the following contents:
Herein, a strategy for visible-light photoredox-catalyzed umpolung carboxylation of diverse carbonyl compounds with CO2 by using Lewis acidic chlorosilanes as activating/protecting groups was reported. This strategy was general and practical to generate valuable α-hydroxycarboxylic acids. It works well for challenging alkyl aryl ketones and aryl aldehydes, as well as for α-ketoamides and α-ketoesters, the latter two of which have never been successfully applied in umpolung carboxylations with CO2 (to the best of our knowledge). This reaction features high selectivity, broad substrate scope, good functional group tolerance, mild reaction conditions and facile derivations of products to bioactive compounds, including oxypheonium, mepenzolate bromide, benactyzine and tiotropium. Moreover, the formation of carbon radicals and carbanions as well as the key role of chlorosilanes are supported by control experiments After reading the article, we found that the author used 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Application In Synthesis of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)
2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Application In Synthesis of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts