Bowman, W. Russell; Bridge, Colin F.; Cloonan, Martin O.; Leach, David C. published the artcile< Synthesis of heteroarenes via radical cyclisation onto nitriles>, Formula: C6H4N2O, the main research area is camptothecin ring system preparation cascade radical cyclization; indolizinoquinolinone preparation cascade radical cyclization.
A new protocol for the synthesis of tetracyclic nitrogen heteroarenes using cascade radical cyclization has been developed. The key steps involve 5-exo vinyl radical cyclization onto nitriles to yield intermediate iminyl radicals which cyclize onto an arene rings. Rings A-D (I) of the anticancer alkaloids camptothecin, mappicine and nothapodytines A and B have been synthesized using this protocol.
Synlett published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (indolizinoquinolinone). 89324-17-4 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H4N2O, Formula: C6H4N2O.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts