Booth, Brian L.; Collis, Alan published the artcile< One-step synthesis of N1-(1-benzylisoquinolin-3-yl)phenylacetamidinium trifluoromethanesulfonate derivatives from phenylacetonitriles and trifluoromethanesulfonic acid>, COA of Formula: C8H5F2N, the main research area is phenylacetonitrile cyclotrimerization triflic acid; benzylisoquinolinylphenylacetamidinium triflate.
The phenylacetonitriles 3,4-R1R2C6H3CH2CN (I, R1 = H, Me, Cl, R2 = H; R1 = H, R2 = Cl, F; R1 = R2 = Cl, F) and 2-cyclohexylphenylacetonitrile react with CF3SO3H under various conditions to give the corresponding title salts, e.g. II, in moderate to high yields. This novel cyclotrimerization reaction can also be carried out with I (R1 = R2 = H) using FSO3H and, in low yield, with HBF4.Et2O while ClSO3H, 4-MeC6H4SO3H, and HCl/ZnCl2 give only PhCH2CONH2 under similar conditions. Reaction of I (R1 = R2 = H) with dry HCl resulted mainly in the formation of 1,3,5-tribenzyltriazine. Isoquinoline formation is not observed upon reaction of either I (R1 = H, MeO, R2 = MeO) with CF3SO3H, but complex product mixtures probably resulting from Houben-Hoesch reactions are obtained. I (R1 = H, R2 = AcO) gives a low yield of the Fries rearrangement product.
Journal of Chemical Research, Synopses published new progress about Cyclotrimerization. 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, COA of Formula: C8H5F2N.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts