The author of 《Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C-H Bond Arylations》 were Benzai, Amal; Shi, Xinzhe; Derridj, Fazia; Roisnel, Thierry; Doucet, Henri; Soule, Jean-Francois. And the article was published in Journal of Organic Chemistry in 2019. Synthetic Route of C7H4BrN The author mentioned the following in the article:
Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as Bifonazole, Climbazole, and Ketoconazole. In the presence of phosphine-free Pd(OAc)2 catalyst, aryl bromides are efficiently coupled at the C5-position of the imidazole units, which are widely decorated. Under these conditions, only the C-H bond arylation reaction occurred without affecting the integrity of chem. structure of the imidazole-based pharmaceuticals. Moreover, with Bifonazole, Pd-catalyzed C-H bond diarylation at the C2- and C5-positions of imidazole unit has also been performed.2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN) was used in this study.
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Synthetic Route of C7H4BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts