Bagley, Mark C’s team published research in Synlett in 2004-11-22 | 6136-93-2

Synlett published new progress about Microwave irradiation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application of C6H11NO2.

Bagley, Mark C.; Chapaneri, Krishna; Glover, Christian; Merritt, Eleanor A. published the artcile< Simple microwave-assisted method for the synthesis of primary thioamides from nitriles>, Application of C6H11NO2, the main research area is nitrile reaction ammonium sulfide microwave irradiation; thioamide primary preparation.

Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 °C or 130 °C in 15-30 min for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H2S under high pressure, proceeds in the absence of base and provides thioamides usually without the need for chromatog. purification

Synlett published new progress about Microwave irradiation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application of C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts