Tidwell, R. R.’s team published research in Journal of Medicinal Chemistry in 1983 | CAS: 83783-33-9

3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Category: nitriles-buliding-blocks

The author of 《Aromatic amidines. Comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin》 were Tidwell, R. R.; Geratz, J. D.; Dubovi, E. J.. And the article was published in Journal of Medicinal Chemistry in 1983. Category: nitriles-buliding-blocks The author mentioned the following in the article:

The title compounds I (R = H, H2NC:NH, NO2; R1 = H or H2NC:NH; R2 = H, Me, Et, benzyl, substituted benzyl; R3 = H, COEt; R4 = H, COH, Ac, COCF3, or Bz) some of which were prepared from the corresponding nitrile derivatives and benzimidazoles by a modified Pinner amidine synthesis, and investigated to determine if the correlation between inhibition of plasmin  [9001-90-5] and(or) urokinase  [9039-53-6] with fusion-blocking activity exists with these compounds 6-amidino-1H-indole-3-carboxaldehyde  [83783-19-1] Was a selective inhibitor of plasmin over thrombin  [9002-04-4], and 5-amidino-1-(4-amidino-2-chlorobenzyl)-1H-indole  [80531-08-4] is a potent new blocker of virus-induced cell fusion. In the experimental materials used by the author, we found 3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9Category: nitriles-buliding-blocks)

3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts