《Optical Control of GABAA Receptors with a Fulgimide-Based Potentiator》 was written by Rustler, Karin; Maleeva, Galyna; Gomila, Alexandre M. J.; Gorostiza, Pau; Bregestovski, Piotr; Koenig, Burkhard. Recommanded Product: 3-Oxo-3-phenylpropanenitrile And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:
Optogenetic and photopharmacol. tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biol. evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABAARs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high-resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Recommanded Product: 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts