The author of 《Studies on antianaphylactic agents. 7. Synthesis of antiallergic 5-oxo-5H-[1]benzopyrano[2,3-b]pyridines》 were Nohara, Akira; Ishiguro, Toshihiro; Ukawa, Kiyoshi; Sugihara, Hirosada; Maki, Yoshitaka; Sanno, Yasushi. And the article was published in Journal of Medicinal Chemistry in 1985. Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The author mentioned the following in the article:
5-Oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acids I and their tetrazole analogs II (R = H, Me, OH, amino; R1 = H, Me; R2 = H, Me, Et, Me2CH, Bu, Me3C, OMe; R1R2 = CH:CHCH:CH) were prepared from 4-oxo-4H-1-benzopyran-3-carbonitriles or 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes. They exhibited antiallergic activity both orally and i.v. in the passive cutaneous anaphylaxis test in rats. With I, the activity was influenced by the substituents at the 2-position and increased in the order: Me, OMe < NH2 < OH, H < NHOMe. Tetrazole series with II, 2-unsubsituted derivatives showed the highest activity. In addition to this study using 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile, there are many other studies that have used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile) was used in this study.
6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts