The author of 《Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances》 were Nohara, Akira; Kuriki, Hisashi; Saijo, Taketoshi; Sugihara, Hirosada; Kanno, Morio; Sanno, Yasushi. And the article was published in Journal of Medicinal Chemistry in 1977. Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The author mentioned the following in the article:
Of 28 title compounds (I; R=H, lower alkyl, Cl, cyclohexyl, OMe, Me2N, OAc, CO2Et, NO2, OH, OBu) and analogs, prepared from the appropriate carboxaldehydes by reaction with NH2OH to give the nitriles followed by cyclization with NaN3 in the presence of AlCl3, most were potent inhibitors of the rat passive cutaneous anaphylaxis reaction. Seven of the compounds were 4-10 times as active as di-Na cromoglycate when administered i.v., and several had oral activity. Structure-activity relations are discussed. In the experimental materials used by the author, we found 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)
6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts