Lu, Wen-Xiu; Xing, Jian; Sun, Yijia; Huang, Qinge; Deng, Zhenwei; Mao, Jian-Gang published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Palladium-catalyzed and alcohol-enabled transformation to synthesize benzocyclic ketones》.Formula: C7H4BrN The article contains the following contents:
A highly effective palladium-catalyzed and alc.-promoted transformation of nitriles to synthesize benzocyclic ketones was described. It provided a straightforward access to potentially valuable indanone compounds in high yields in the presence of alc. It avoided the usage of carbon monoxide or an addnl. hydrolysis procedure. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Formula: C7H4BrN)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Formula: C7H4BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts