Name: 4-Cyanobenzyl bromideIn 2019 ,《Catalyst-Free Sulfonylation of (Hetero)aryl Iodides with Sodium Dithionite》 was published in Advanced Synthesis & Catalysis. The article was written by Li, Yuewen; Liu, Tong; Qiu, Guanyinsheng; Wu, Jie. The article contains the following contents:
The com. available and cheap sodium dithionite was used as the source of sulfonyl group for the synthesis of heteroaryl-sulfones I [R = n-Pr, Ph, 4-MeC6H4, etc.; R1 = 2-thienyl, 2-pyridyl, 2-pyrimidinyl, etc.] and sulfonamides II [R2 = Et, Ph; R3 = Me, Et; R2R3 = (CH2)4, (CH2)2O(CH2)2, (CH2)2S(CH2)2] from heteroaryl-iodides under catalyst-free conditions. During the reaction process, sodium sulfinates generated in situ were the key intermediate, which further converted into heteroaryl-sulfones I and sulfonamides II by treating with bromoalkanes and amines resp. This transformation proceeded through a radical process initiated by sodium dithionite, providing a convenient route to sulfonyl-containing compounds The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Name: 4-Cyanobenzyl bromide)
4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Name: 4-Cyanobenzyl bromide
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts