In 2022,Altan, Orhan published an article in Applied Organometallic Chemistry. The title of the article was 《A rare example of the in-situ formation of palladium nanoparticles: The emergence of catalytically active palladium nanoparticles from Pd (II) phosphine complexes in the Suzuki-Miyaura coupling reaction》.Name: 2-Bromobenzonitrile The author mentioned the following in the article:
Pd (II) complexes of phosphino-benzaldoxime ligands were synthesized, characterized and tested in SMC reactions. Interestingly, it was found that the catalytic activity increased by 11 times when the amount of catalyst was reduced by 10-fold and increased by five times when the amount of catalyst was decreased by 100-fold. The detailed analyses revealed that the palladium nanoparticles (NPs) are responsible for the catalytic activity which was formed in the reaction medium. A plausible mechanism was proposed for the formation of Pd NPs from palladium phosphino-benzaldoxime complexes in the reaction medium. This study is expected to contribute to the debate over whether the catalytic activity of phosphine-palladium complexes in SMC reactions results from a homogeneous or heterogeneous pathway. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Name: 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts