Zhu, Ruiheng; Reddy, Ramesh; Ding, Man; Xu, Ming; Deng, Chaoyi; Tadayon, Sam; Li, Hui; Depew, Kristopher; Lane, Benjamin published an article in 2021. The article was titled 《Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction》, and you may find the article in Organic Process Research & Development.COA of Formula: C9H7NO The information in the text is summarized as follows:
The development of a continuous manufacturing process for a hydrazine condensation reaction at high temperature was reported. This continuous process represented a safer approach to manufacture 3-phenyl-1H-pyrazol-5-amine at scale and exhibited better impurity control compared to a traditional batch process. A controlled crystallization allowed consistently low levels of residual hydrazine (<20 ppm) in isolated solids for further processing to final drug substance. The scalability and robustness of the continuous process was demonstrated at 3 kg scale with a throughput of 0.5 kg/h.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4COA of Formula: C9H7NO) was used in this study.
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.COA of Formula: C9H7NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts