Formula: C11H8N2On September 29, 2010 ,《A Highly Selective Low-Background Fluorescent Imaging Agent for Nitric Oxide》 was published in Journal of the American Chemical Society. The article was written by Yang, Youjun; Seidlits, Stephanie K.; Adams, Michelle M.; Lynch, Vincent M.; Schmidt, Christine E.; Anslyn, Eric V.; Shear, Jason B.. The article contains the following contents:
The authors introduce a novel sensing mechanism for nitric oxide (NO) detection with a particular easily synthesized embodiment (NO550), which displays a rapid and linear response to NO with a red shifted 1500-fold turn-on signal from a dark background. Excellent selectivity was observed against other reactive oxygen/nitrogen species, pH, and various substances that interfere with existing probes. NO550 crosses cell membranes but not nuclear membranes and is suitable for both intra- and extracellular NO quantifications. Good cytocompatibility was found during in vitro studies with two different cell lines. The high specificity, dark background, facile synthesis, and low pH dependence make NO550 a superior probe for NO detection when used as an imaging agent. In the part of experimental materials, we found many familiar compounds, such as 5-Amino-1-naphthonitrile(cas: 72016-73-0Formula: C11H8N2)
5-Amino-1-naphthonitrile(cas: 72016-73-0) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C11H8N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts