Yadav, Maruti B.; Jeong, Yeon Tae published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《A one-pot ring-closure and ring-opening sequence for the cascade synthesis of dihydrofurofurans and functionalized furans》.Formula: C9H7NO The article contains the following contents:
Authors have developed a simple novel ring-closure and ring-opening pathway using an organo-base system for the synthesis of highly substituted dihydrofurofuran and furan frameworks via a triethylamine-catalyzed one-pot three-component reaction. The protocol involved a Knoevenagel and Michael adduct via Paal-Knorr cyclization with aromatic/aliphatic glyoxal and 2-cyanoacetophenone under mild and heating conditions with excellent yields through a simple filtration method. The merits of this methodol., including the use of easily available feedstocks and an inexpensive catalyst, Gram-scale synthesis, wide functional group tolerance, an open-air reaction setup, and no need for workup and column-chromatog. procedures, make the developed methodol. a practical way to access dihydrofurofurans and functionalized furans. After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts