In 2006,Stachulski, Andrew V.; Berry, Neil G.; Low, A. C. Lilian; Moores, Shelley L.; Row, Eleanor; Warhurst, David C.; Adagu, Ipemida S.; Rossignol, Jean-Francois published 《Identification of Isoflavone Derivatives as Effective Anticryptosporidial Agents in Vitro and in Vivo》.Journal of Medicinal Chemistry published the findings.Recommanded Product: 31938-07-5 The information in the text is summarized as follows:
The preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein was reported. The prepared analogs retain the 5,7-dihydroxyisoflavone core of genistein. Genistein analogs I (R2 = R3 = H, R4 = NO2, Br; R2 = R4 = H, R3 = NO2, Br), 2-carboethoxyisoflavones I (R2 = CO2Et, R3 = H, R4 = NO2, Br; R2 = CO2Et, R3 = NO2, Br, R4 = H), and the corresponding precursor deoxybenzoins II were all evaluated. Excellent in vitro activity against Cryptosporidium parvum was observed for both classes of isoflavones in cell cultures, and the lead compound RM 6427 I (R2 = CO2Et, R3 = Br, R4 = H), showed high in vivo efficacy against an exptl. infection. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Recommanded Product: 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts