In 2022,Salaverri, Noelia; Carli, Benedetta; Gratal, Patricia B.; Marzo, Leyre; Aleman, Jose published an article in Advanced Synthesis & Catalysis. The title of the article was 《Remote Giese Radical Addition by Photocatalytic Ring Opening of Activated Cycloalkanols》.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:
The addition of these remote alkyl radicals RC(R1)(R2)OH [R = Me, 4-methoxyphenyl, furan-2-yl, etc.; R1R2 = -(CH2)5-, -CH2S(CH2)2-, -CH2N(Boc)(CH2)3-, etc.] to electron deficient double bonds R3CH=C(R4)CN (R3 = Ph, thiophen-2-yl, naphthalen-1-yl, etc.; R4 = CN, C(O)Ph, 4-nitrophenyl, etc.) under photoorganocatalyzation and very mild conditions was reported. The method not only applicable to diactivated double bonds, but monoactivated ones are also accessible using more stabilized alkyl radicals, and alkyl chains of any length can be introduced. The final products RC(O)(CH2)nCH2C(R3)CH(R4)CN (n = 2, 4, 6, etc.) can be easily converted into more complex structures via a one-pot process, and the activating functional groups were transformed in the more versatile Me esters. Mechanistic investigations support a mechanistic proposal based on a PCET process. After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts