Pang, Xiaobo; Zhao, Zhen-Zhen; Wei, Xiao-Xue; Qi, Liangliang; Xu, Guang-Li; Duan, Jicheng; Liu, Xue-Yuan; Shu, Xing-Zhong published their research in Journal of the American Chemical Society in 2021. The article was titled 《Regiocontrolled Reductive Vinylation of Aliphatic 1,3-Dienes with Vinyl Triflates by Nickel Catalysis》.Recommanded Product: 2042-37-7 The article contains the following contents:
The regiocontrolled functionalization of 1,3-dienes has become a powerful tool for divergent synthesis, yet it remains a long-standing challenge for aliphatic substrates. Herein, the authors report a reductive approach for a branch-selective 1,2-hydrovinylation of aliphatic 1,3-dienes with R-X electrophiles, which represents a new selectivity pattern for diene functionalization. Simple butadiene, aromatic 1,3-dienes, and highly conjugated polyene were also tolerated. The combination of Ni(0) and the phosphine-nitrile ligand generally resulted in >20:1 regioselectivity with the retention of the geometry of the C3-C4 double bonds. This reaction proceeds with a broad substrate scope, and it allows for the conjugation of two biol. active units to form more complex polyene mols., such as tetraene and pentaene as well as heptaene. The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2042-37-7)
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2042-37-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts