《Triflic Acid as an Efficient Bronsted Acid Promoter for the Umpolung of N-Ac Indoles in Hydroarylation Reactions》 was published in Advanced Synthesis & Catalysis in 2018. These research results belong to Nandi, Raj Kumar; Perez-Luna, Alejandro; Gori, Didier; Beaud, Rodolphe; Guillot, Regis; Kouklovsky, Cyrille; Gandon, Vincent; Vincent, Guillaume. Safety of 3-Formyl-1H-indole-6-carbonitrile The article mentions the following:
We report that triflic acid, a strong Bronsted acid, is a very powerful alternative to FeCl3 to mediate the hydroarylation of N-Ac indoles, which delivers regioselectively 3-arylindolines, 3,3-spiroindolines or 2-arylindolines. Mechanistic explorations point towards the existence of a highly electrophilic intermediate by simultaneous activation of the acetyl and of the C2=C3 bond by protons. After reading the article, we found that the author used 3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9Safety of 3-Formyl-1H-indole-6-carbonitrile)
3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Safety of 3-Formyl-1H-indole-6-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts