Synthetic Route of C8H6BrNIn 2016 ,《Rhodium-Catalyzed Enantioselective Silylation of Cyclopropyl C-H Bonds》 was published in Angewandte Chemie, International Edition. The article was written by Lee, Taegyo; Hartwig, John F.. The article contains the following contents:
Hydrosilyl ethers, generated in situ by the dehydrogenative silylation of cyclopropylmethanols with diethylsilane, undergo asym., intramol. silylation of cyclopropyl C-H bonds in high yields and with high enantiomeric excesses in the presence of a Rh catalyst derived from a Rh precursor and the bisphosphine (S)-DTBM-SEGPHOS. The resulting enantioenriched oxasilolanes are suitable substrates for the Tamao-Fleming oxidation to form cyclopropanols with conservation of the ee value from the C-H silylation. Preliminary mechanistic data suggest that C-H cleavage probably is the turnover-limiting and enantioselectivity-determining step. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Synthetic Route of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts