Jiang, Min; Li, Haifang; Yang, Haijun; Fu, Hua published the artcile< Room-Temperature Arylation of Thiols: Breakthrough with Aryl Chlorides>, Application of C8H6ClN, the main research area is aryl sulfide preparation; thiol aryl halide visible light photoredox arylation; C−S coupling; arylation; photocatalysis; synthetic methods; thiols.
The formation of aryl C-S bonds is an important chem. transformation because aryl sulfides are valuable building blocks for the synthesis of biol. and pharmaceutically active mols. and organic materials. Aryl sulfides have traditionally been synthesized through the transition-metal-catalyzed cross-coupling of aryl halides with thiols. However, the aryl halides used are usually bromides and iodides; readily available, low-cost aryl chlorides often not reactive enough. Furthermore, the deactivation of transition-metal catalysts by thiols has forced chemists to use high catalyst loadings, specially designed ligands, high temperatures, and/or strong bases, thus leading to high costs and the incompatibility of some functional groups. Herein, we describe a simple and efficient visible-light photoredox arylation of thiols with aryl halides at room temperature More importantly, various aryl chlorides are also effective arylation reagents under the present conditions.
Angewandte Chemie, International Edition published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Application of C8H6ClN.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts