Computed Properties of C43H30F2N4On October 11, 2020 ,《Photocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction》 was published in Chemistry – A European Journal. The article was written by Donabauer, Karsten; Murugesan, Kathiravan; Rozman, Ursa; Crespi, Stefano; Koenig, Burkhard. The article contains the following contents:
A photocatalytic approach to the Corey-Seebach reaction has been described. The presented method operates under mild redox-neutral and base-free conditions giving the desired product with high functional group tolerance. The reaction is enabled by the combination of photo- and hydrogen atom transfer (HAT) catalysis. This catalytic merger allows a C-H to carbanion activation by the abstraction of a hydrogen atom followed by radical reduction The generated nucleophilic intermediate is then capable of adding to carbonyl electrophiles. By this approach, dithianes I (R1 = Me, NCCH2CH2, PhCH2CH2, etc.) were reacted with various aldehydes and ketones R2C(O)R3 [R2 = Et, i-Pr, MeSCH2CH2, R3 = H; R2 = n-Pr, i-Pr, PhCH2CH2, etc., R3 = Me; R2R3 = (CH2)3, (CH2)2O(CH2)2, etc.] giving access to the valuable α-hydroxy dithianes II. The proposed reaction mechanism is supported by emission quenching, radical-radical homocoupling and deuterium labeling studies as well as by calculated redox-potentials and bond strengths. In the experiment, the researchers used 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Computed Properties of C43H30F2N4)
2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Computed Properties of C43H30F2N4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts