《Metal-Free and Regioselective Synthesis of Substituted and Fused Chromenopyrrole Scaffolds via the Divergent Reactivity of α-Azido Ketones in Water》 was published in Journal of Organic Chemistry in 2020. These research results belong to Dhanasekar, Elumalai; Kannan, Tharanikkarasu; Venkatesan, Rengarajan; Perumal, Paramasivam Thirumalai; Kamalraja, Jayabal. Safety of 3-Oxo-3-phenylpropanenitrile The article mentions the following:
A green and simple approach was developed for the regioselective synthesis of structurally diverse chromenopyrrole frameworks from 3-formylchromones, active methylenes and α-azido ketones using piperidine as a catalyst in the aqueous medium through a tandem one pot multi-component reaction. Further, the synthesized pyrrole framework was successfully converted into biol. significant 6-azaindole derivatives in simple synthetic transformation. An exciting feature of this synthetic protocol is that the reaction mechanism and formation of the products depend on the nature of the active methylene used. This approach has several advantages such as transition metal-free catalyst, a short reaction time, easy separation, an excellent yield, practically simple execution, high regioselectivity, very good atom economy, low E-factor, and no requirement of toxic solvents and chromatog. purification The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Safety of 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts