Baudoin, Olivier; Guenard, Daniel; Gueritte, Francoise published their research in Journal of Organic Chemistry on December 29 ,2000. The article was titled 《Palladium-Catalyzed Borylation of Ortho-Substituted Phenyl Halides and Application to the One-Pot Synthesis of 2,2′-Disubstituted Biphenyls》.Product Details of 325141-71-7 The article contains the following contents:
The title reactions are described. Thus, Pd(OAc)2/2-(dicyclohexylphosphino)biphenyl-catalyzed borylation of 2-BrC6H4NH2 with pinacolborane in the presence of Et3N in dioxane gave 81% pinacol (2-aminophenyl)boronate which in situ underwent Suzuki coupling with 2-IC6H4CH2CN/Ba(OH)2 to give 73% 2′-aminobiphen-2-ylacetonitrile. The experimental part of the paper was very detailed, including the reaction process of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7Product Details of 325141-71-7)
2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Product Details of 325141-71-7 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts