Utimoto, Kiitiro; Wakabayashi, Yukio; Shishiyama, Yuho; Inoue, Masaharu; Nozaki, Hitosi published the artcile< 2-Alkoxy- and 2,2-dialkoxynitriles from acetals and ortho esters: exchange of alkoxy into cyano group by means of cyanotrimethylsilane>, Name: 2,2-Diethoxyacetonitrile, the main research area is acetal aromatic aliphatic cyanation; ortho ester cyanation catalyst; tin fluoroborane cyanation catalyst; borane fluoro catalyst cyanation; alkoxynitrile; nitrile alkoxy; methoxyacetonitrile lithiation octylation oxidation; acetonitrile methoxy lithiation octylation oxidation; nonanoate.
Thirteen RCR1(OR2)CN (R = H, alkyl, Ph, PhCH2; R1 = H, OMe, OEt; R2 = Me, Et) were prepared in 64-97% yield by cyanation of the corresponding RCR1(OR2)2 with Me3SiCN in the presence of SnCl2 or BF3.OEt2 catalysts. E.g., 80% (MeO)2CHCN (I) was obtained on treatment of (MeO)3CH with 1 equiv Me3SiCN and a catalytic amount of BF3.OEt2 at room temperature I was converted to Me(CH2)7CO2Me by sequential treatment with LiN(CHMe2)2, Me(CH2)7Br, and p-MeC6H4SO3H in Me2CO-H2O.
Tetrahedron Letters published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Name: 2,2-Diethoxyacetonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts