Huang, Chun; Zhou, You; Yu, Xiao-Xiao; Wang, Li-Sheng; Wu, Yan-Dong; Wu, An-Xin published the artcile< I2/CuCl2-Copromoted Formal [4 + 1 + 1] Cyclization of Methyl Ketones, 2-Aminobenzonitriles and Ammonium Acetate: Direct Access to 2-Acyl-4-aminoquinazolines>, Electric Literature of 38487-85-3, the main research area is aminoquinazolinyl aryl methanone preparation; aryl ethanone aminobenzonitrile ammonium acetate cyclization.
An I2/CuCl2-copromoted diamination of C(sp3)-H bonds for the preparation of 2-acyl-4-aminoquinazolines I [Ar = Ph, 1-naphthyl, 4-MeOC6H4, etc.; R = 8-Me, 6-Cl, 7-MeO, etc.] from Me ketones, 2-aminobenzonitriles, and ammonium acetate was reported. This reaction featured operational simplicity, com. available substrates, mild reaction conditions, and good functional group compatibility. Mechanistic studies indicated that CuCl2 played a pivotal role in this transformation. This study uses a Me group as a novel input to construct 2-acyl-4-aminoquinazoline derivatives for the first time.
Journal of Organic Chemistry published new progress about Amination. 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Electric Literature of 38487-85-3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts