Gao, Xiang; Liu, Jiao; Liu, Zhaopeng; Zhang, Lei; Zuo, Xin; Chen, Leyuan; Bai, Xue; Bai, Qingyun; Wang, Xinlin; Zhou, Anning published the artcile< DBU coupled ionic liquid-catalyzed efficient synthesis of quinazolinones from CO2 and 2-aminobenzonitriles under mild conditions>, Recommanded Product: 2-Amino-4-methoxybenzonitrile, the main research area is quinazolinone preparation organic base ionic liquid catalyst; aminobenzonitrile carbon dioxide cyclization diazabicycloundecene ionic liquid catalyst.
An efficient catalytic system of organic base-coupled ionic liquids (ILs) that could catalyze the synthesis of quinazolinones I (R1 = H, OMe, Cl, Br, R2 = H; R1 = H, R2 = Cl) via cyclization of 2-aminobenzonitriles with CO2 under mild conditions (e.g., 60°C, 0.1 MPa) was reported. It was found that 1,8-diazabicyclo[5.4.0]undec-7-ene coupled with 1-butyl-3-methylimidazole acetate ionic liquids, (DBU/[Bmim][OAc]), displayed excellent performance in catalyzing the reactions of CO2 with 2-aminobenzonitriles to give compounds I in high yields at atm. pressure. Moreover, the ILs had high stability and reusability, and could be reused at least five times without considerable decrease in catalytic activity. This protocol could also be conducted on a gram scale, and may have promising and practical applications in the production of quinazolinones.
RSC Advances published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Recommanded Product: 2-Amino-4-methoxybenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts