Flemmich, Laurin; Moreno, Sarah; Micura, Ronald published the artcile< Synthesis of O6-alkylated preQ1 derivatives>, Computed Properties of 69205-79-4, the main research area is alkoxy pyrrolopyrimidinyl aminotrifluoroacetate salt preparation; RNA cofactors; RNA methylation; deazapurines; heterocycles; pyrrolopyrimidines; queuosine.
A robust synthesis for the class of pyrrolo[2,3-d]pyrimidines starting from readily accessible N2-pivaloyl-protected 6-chloro-7-cyano-7-deazaguanine. Substitution of the 6-chloro atom with the alcoholate of interest proceeded straightforward. The transformation of the 7-cyano substituent into the required aminomethyl group turned out to be challenging and was solved by a hydration reaction sequence on a well-soluble dimethoxytritylated precursor via in situ oxime formation. The synthetic path provided a solid foundation to access O6-alkylated 7-aminomethyl-7-deazaguanines for the development of RNA labeling tools based on the preQ1 class-I riboswitch scaffold.
Beilstein Journal of Organic Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 69205-79-4 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H5N5O, Computed Properties of 69205-79-4.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts