Wan, Bin; Lu, Zhuoer; Wu, Zhuo; Cheng, Cang; Zhang, Yanghui published the artcile< Diastereoselective Construction of Eight-Membered Carbocycles through Palladium-Catalyzed C(sp3)-H Functionalization>, COA of Formula: C8H5BrFN, the main research area is alkylphenyl bromide biphenylene palladium catalyst diastereoselective cross coupling reaction; dihydrotribenzoannulene preparation.
A palladium-catalyzed cross-coupling reaction of 2-alkylphenyl bromides with biphenylene was developed. The reactions formed eight-membered carbocycles through C(sp3)-H activation and the formation of two C-C bonds, and the chiral products were obtained with excellent diastereoselectivity. The reaction provided a new strategy for the construction of eight-membered carbocycles, and the products represent a novel type of chiral scaffold.
Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, COA of Formula: C8H5BrFN.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts