Taldone, Tony; Patel, Pallav D.; Patel, Hardik J.; Chiosis, Gabriela published the artcile< About the reaction of aryl fluorides with sodium sulfide: investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine>, COA of Formula: C7H3ClFN, the main research area is mercaptobenzonitrile synthesis aryl fluoride sulfide substitution.
In this report we describe a simple synthesis of mercaptobenzonitriles from the reaction of fluorobenzonitriles with Na2S in DMF at room temperature and following direct treatment with Zn/HCl. Significantly, 2- and 4-fluorobenzonitriles substituted with chlorine or bromine, but not iodine, undergo selective substitution of fluorine at room temperature to yield synthetically useful halo-substituted mercaptobenzonitriles.
Tetrahedron Letters published new progress about Aromatic substitution reaction. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, COA of Formula: C7H3ClFN.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts