Petritsch, Markus; Seebacher, Werner; Mohsin, Noor-ul-Amin; Dolensky, Johanna; Hochegger, Patrick; Kaiser, Marcel; Maeser, Pascal; Belaj, Ferdinand; Saf, Robert; Kretschmer, Nadine; Alajlani, Muaaz; Brantner, Adelheid; Bauer, Rudolf; Schuehly, Wolfgang; Weis, Robert published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities》.SDS of cas: 17201-43-3 The article contains the following contents:
New 1,3 dibenzyl -tetrahydropyridinylidene ammonium salts I [R1R2 = -(CH2)4-, -(CH2)5-; R3 = Ph, 4-chlorophenyl, 2,6-dichlorophenyl, etc.; R4 = Ph, 4-chlorophenyl, 2,6-dichlorophenyl, etc.] were prepared from unsubstituted or N-benzylated tetrahydropyridinylidene ammonium salts II and III. The antiplasmodial and antitrypanosomal activities as well as their cytotoxic effects were determined using microplate assays. In addition, their activities against two gram pos. and two gram neg. bacteria strains and a yeast strain were examined Furthermore, anticancer effects against two cell lines were investigated. Physicochem. parameters were calculated and structure-activity-relationships discussed. One compound showed antiplasmodial activity against a multiresistant strain of Plasmodium falciparum in subnanomolar concentration Antitrypanosomal activities were detected in low nanomolar concentrations A single compound was active against gram pos. and gram neg. bacteria, as well as yeast. One compound inhibited the growth of a HCT cell line in low concentration In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3SDS of cas: 17201-43-3)
4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.SDS of cas: 17201-43-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts