Category: nitriles-buliding-blocksIn 2010 ,《New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Gommermann, Nina; Buehlmayer, Peter; von Matt, Anette; Breitenstein, Werner; Masuya, Keiichi; Pirard, Bernard; Furet, Pascal; Cowan-Jacob, Sandra W.; Weckbecker, Gisbert. The article conveys some information:
A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies toward activity and selectivity are described, leading to Lck inhibitors with enzymic, cellular, and in vivo potency. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Category: nitriles-buliding-blocks) was used in this study.
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts