Flores-Gaspar, Areli; Martin, Ruben published the artcile< Mechanistic Switch via Subtle Ligand Modulation: Palladium-Catalyzed Synthesis of α,β-Substituted Styrenes via C-H Bond Functionalization>, Recommanded Product: 2-(2-Bromo-5-fluorophenyl)acetonitrile, the main research area is palladium catalyst aldehyde bromophenylmethyl olefination; alkene aryl preparation.
A new catalyst system for the efficient use of aldehydes I [R1 = H, F, MeO, etc.; R2 = H, Cl, etc.; R3 = H, 3-HO, 3,5-Me2, etc.] for the synthesis of styrenes II via C-H bond functionalization and a subtle ligand modification is described. The high level of activity achieved allows to synthesize highly functionalized α,β-substituted styrenes, even the elusive E-configured trisubstituted olefins, in a regio- and stereoselective manner. Mechanistic experiments allowed to identify the corresponding synthetic intermediates.
Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Recommanded Product: 2-(2-Bromo-5-fluorophenyl)acetonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts