In 2011,de Koning, Pieter D.; Murtagh, Lorraine; Lawson, Jon P.; Vonder Embse, Richard A.; Kunda, Sastry A.; Kong, Wei published 《Development an efficient route to the 5-lipoxygenase inhibitor PF-04191834》.Organic Process Research & Development published the findings.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:
A convergent six-step process for the synthesis of PF-04191834 (I), a potent and selective 5-lipoxygenase inhibitor, has been developed and used to deliver over 20 kg of API. The process uses the same bond-forming steps as the initial medicinal chem. route, including the use of two consecutive Pd-catalyzed Ar-S couplings to form the key diaryl thioether linkage. The reaction conditions and downstream processing have been optimized to eliminate column chromatog. and aqueous work-ups and to minimize disproportionation of I, to ensure successful scale-up. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application In Synthesis of 2-(3-Bromophenyl)acetonitrile)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts