Dai, Weixiang; Petersen, Jeffrey L.; Wang, Kung K. published the artcile< Synthesis of the Parent and Substituted Tetracyclic ABCD Ring Cores of Camptothecins via 1-(3-Aryl-2-propynyl)- 1,6-dihydro-6-oxo-2-pyridinecarbonitriles>, Related Products of 89324-17-4, the main research area is camptothecin ABCD ring core preparation nitrogen alkylation Curran’s protocol; intramol hetero Diels Alder acetylene allene rearrangement radical cyclization; radical cyclization reaction mechanism camptothecin core preparation; crystal mol structure indolizinoquinolinone camptothecin ring core analog.
A new synthetic pathway to the parent and substituted ABCD ring cores, e.g. I, of the camptothecin family of alkaloids was developed. The N-alkylation of 1,6-dihydro-6-oxo-2-pyridinecarbonitrile with 3-bromo-1-phenylpropyne provided II using Curran’s protocol. Treatment of II with a catalytic amount of DBU (5 mol %) at 110 °C for 12 h produced indolizino[1,2-b]quinolin-9(11H)-one (I), the parent ABCD ring core of camptothecin, in essentially quant. yield.
Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 89324-17-4 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H4N2O, Related Products of 89324-17-4.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts