Bochis, Richard J.; Chabala, John C.; Harris, Ellwood; Peterson, Louis H.; Barash, Louis; Beattie, Thomas; Brown, Jeannette E.; Graham, Donald W.; Waksmunski, Frank S. published the artcile< Benzylated 1,2,3-triazoles as anticoccidiostats>, Recommanded Product: 2-Chloro-4-methylbenzonitrile, the main research area is triazole benzylated preparation anticoccidiostat; carbamoylaminotriazole preparation anticoccidiostat; structure activity carbamoylaminotriazole anticoccidiostat; aminobenzylcarbamoyltriazole preparation anticoccidiostat; benzyltriazole aminocarbamoyl preparation anticoccidiostat.
Substituted aminocarbamoyltriazoles I (R = Cl, H, COC6H4Cl-4; R1 = COC6H4R3, COPh, H, Cl, R3 = 4-Cl, 4-F, 4-cyano, 4-CO2Me, 4-CCl:CCl2, 4-Br, 4-iodo; R1 = COC6H3Cl2-3,4, COC6H3Cl2-2,6, etc.; R2 = H, Cl, F, Br) were prepared and evaluated in vivo for anticoccidial activity. Thus, N-alkylation of 5-amino-4-carbamoyl-1,2,3-triazole with benzene derivatives II (R4 = Br) gave I. Cyclization of II (R4 = N3) with 2-cyanoacetamide also gave I. I (R = R2 = Cl, R1 = COC6H4Cl-4) is a highly effective coccidiostat. An increase in activity was observed when the CO of the benzophenone moiety is flanked by halogens as in I (R = R2 = Cl, R1 = COC6H4Cl-4; R = R2 = Cl, R1 = COPh).
Journal of Medicinal Chemistry published new progress about Coccidiostats. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Recommanded Product: 2-Chloro-4-methylbenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts