In 2019,Chinese Journal of Chemical Engineering included an article by Ansari, Rasheeda M.; Mahesh, Lolakshi K.; Bhat, Badekai Ramachandra. Application In Synthesis of 4-Bromobenzonitrile. The article was titled 《Cobalt Schiff base complexes: synthesis characterization and catalytic application in Suzuki-Miyaura reaction》. The information in the text is summarized as follows:
3-Methoxysalicylaldehyde was condensed with the amines 4-aminoacetophenone and 2-amino-5-bromopyridine to obtain Schiff base ligands, 1 and 2, which were coordinated to cobalt salts as complex 1 and complex 2, resp. The synthesized ligands and complexes were characterized by spectroscopic (FT-IR, UV-Vis, 1H-NMR and mass spectrometry), thermal (TGA) and elemental anal. The structures of the complexes were verified by evaluating their magnetic susceptibility and spectroscopic evidences. Synthesized complexes were studied for their catalytic activity in the Suzuki-Miyaura cross-coupling of aryl halides with phenylboronic acid. Optimized reaction yields 90% of the cyanobiphenyl for complex 1 and 91% for complex 2 with 0.1 mmol of catalyst loading thereby substantiating the C-C coupling efficiency of the synthesized complexes, 1 and 2. In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Application In Synthesis of 4-Bromobenzonitrile)
4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application In Synthesis of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts