In 2007,Aly, Youssef L.; Pedersen, Erik B.; La Colla, Paolo; Loddo, Roberta published 《Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group》.Archiv der Pharmazie (Weinheim, Germany) published the findings.SDS of cas: 31938-07-5 The information in the text is summarized as follows:
Synthesis and antiviral activities are reported of a series of 6-(3-alkynyl benzyl)-substituted analogs of MKC-442 (6-benzyl-1-(ethoxymethyl)-5-isopropyluracil), a highly potent agent against HIV. The 3-alkynyl group is assumed to give a better stacking of the substituted benzyl group to reverse transcriptase (RT) and this was believed to improve antiviral activity against HIV-1. The bromo derivatives, 5-alkyl-6-(3-bromo-benzyl)-1-ethoxymethyl derivatives 7a, b and 5-alkyl-6-(3-bromobenzyl)-1-allyloxymethyl derivatives 9a, b, showed activity against HIV on the same level as their corresponding analogs 10a-d with a 3-trimethylsilylalkynylbenzyl substituent and their desilylated analogs 11a-d. However, they all showed activity against HIV-1 wild type in the range of more than 10fold lower than the one of MKC-442. Moderate activity against Y181C and Y181C + K103N mutated strains was also observed and, in some cases, they were marginally better than those found for MKC-442. A few amino-DABO and S-DABO analogs were also synthesized but they were found to be inactive against HIV. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.SDS of cas: 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts