Xie, Hao; Xing, Qiaoyan; Shan, Zhifei; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Nickel-Catalyzed Annulation of o-Haloarylamidines with Aryl Acetylenes: Synthesis of Isoquinolone and 1-Aminoisoquinoline Derivatives>, SDS of cas: 21423-84-7, the main research area is isoquinolone aminoisoquinoline benzoimidazoisoquinoline preparation regioselective; haloarylamidine aryl acetylene annulation nickel catalyst.
An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives I (R1 = H, 8-Me, 6-F etc.; R2 = H, 4-Me, 3-Cl, etc.; R3 = H, Me, n-Bu, Ph, COOEt; R4 = Ph, 4-MeC6H4, 3-pyridyl, etc.) via nickel-catalyzed annulation of substituted 2-halobenzamidines with aryl alkynes in the presence of water is described. Benzo[4,5]imidazo[2,1-a]isoquinolines II (R1 = R2 = H; R3 = H, C6H5; R4 = C6H5, 4-FC6H4, 4-MeOC6H4, etc.) were formed as the dominated products when dry DMSO was used as the solvent. Furthermore, when benzyl substituted amidines were used as the substrates, debenzylation reaction occurred to provide various 1-aminoisoquinoline products.
Advanced Synthesis & Catalysis published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, SDS of cas: 21423-84-7.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts